THESIS ON MACROCYTIC ANEMIA

This article has been cited by other articles in PMC. Support Center Support Center. Considering megaloblastic anaemia as one of the differentials in pancytopenia is important. Macrocytic anemia was diagnosed in patients with 1. Macrocytosis, mild anemia and delay in diagnosis of pernicious anemia. To evaluate utilization of bone marrow examination and upper GI endoscopy in diagnosis of megaloblastic anemia. Med Clin North Am.

Status of laboratory testing in the diagnosis of megaloblastic anemia. To search for and identification of distinct clinical features may help to diagnose megaloblastic anemia and also may help in the early identification of low levels of B12 or folic acid. Even though many diseases might lead to macrocytic anemia our study shows megaloblastic macrocytosis as the most common cause. Megaloblastic anemia due to Vitamin B 12 or folate deficiency remains the most important cause of macrocytic anemia. Interpretation of electronically determined macrocytosis.

To evaluate the causes for megaloblastic anemia. This article has been cited by other articles in PMC.

This demonstrates that megaloblastosis still remains the most significant reason for macrocytic anemia in our population which causes substantial morbidity.

Med Clin North Am. The high prevalence of tropical sprue as established in this study has not been revealed in any other study before. This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia.

An increased value of MCV, among various other findings at regular laboratory investigations, might be the early feature of various disease states like low vitamin B12 or low folate levels, pre leukemia, drug induced or alcoholism7.

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This emphasises the significance of evaluating tropical sprue in a suitable settings to the clinician. The severity of anemia did not have any correlation with the levels of serum B12 or the degree of macrocytosis.

Macrocytosis is common in various clinical settings and it is found in approximately 1. Author information Article notes Copyright and License information Disclaimer.

Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia

Etiology and diagnostic evaluation of macrocytosis. Macrocytosis would be thewis even in the absence of anemia. Support Center Support Center. Although our study had very small number of cases with drug exposure, clinical history of drug intake is essential in evaluating for megaloblastic anemia. Even though many diseases might lead to macrocytic anemia our study shows megaloblastic macrocytosis as the most common cause.

Etiological Profile of Macrocytic Anemia in Patients Admitted in PSG Hospitals

Anemia with a hemoglobin of; a. Considering macrocyyic anaemia as one of the differentials in pancytopenia is important. Result The most common cause of macrocytic anemia was megaloblastic anemia Disorders that affect the synthesis of DNA in the precursors of erythrocytes anmeia to megaloblastic anemia and other disorders through various processes causes non-megaloblastic anemia.

In settings with limited laboratory facilities, a therapeutic trial of vitamins B 12 or folic acid is useful in determining the specific vitamin deficiency.

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thesis on macrocytic anemia

Received Jun 3; Accepted Sep Conclusion Megaloblastic anemia due to Vitamin B 12 or folate deficiency remains the most important cause of macrocytic anemia. Patients above the age of 15 years with macrocytic anemia. Macrocytic anemia, Non-megaloblastic macrocytic anemia, Bone marrow disorders, Megaloblastic anemia, Myelodysplastic syndrome.

Interpretation of electronically determined macrocytosis. Megaloblastic anemia macrcoytic to Vitamin B 12 or folate deficiency remains the most important cause of macrocytic anemia.

Badhe2 Zachariah Bobby3 and Ashish K. Post splenectomy and pregnant patients.

thesis on macrocytic anemia

High mean red cell volume: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. Abstract Purpose of study This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia. A systematic approach to macrocytosis. Vitamin B 12 deficiency and early rise in MCV.

thesis on macrocytic anemia

Three patients mean age 55 years with a megaloblastic marrow did not respond to vitamin replacement and were found to have myelodysplastic syndrome. Patients with decompensated liver disease, chronic kidney disease, Hemolytic anemia, Hemorrhagic disease.

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